Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 10/20 | 0.69 |
| ▸ | MAOA | P21397 | 10/20 | 0.56 |
| ▸ | MAOB | P27338 | 9/20 | 0.56 |
| ▸ | RCOR1 | Q9UKL0 | 3/20 | 0.56 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.56 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.55 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.55 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15780111 | 1.00 | KDM1A (0.69) | KDM1AMAOAMAOBRCOR1KDM1B | |
| SCHEMBL22335139 | 0.89 | NR1H4 (0.56) | KDM1AMAOAMAOBRCOR1KDM1B | |
| SCHEMBL22334926 | 0.88 | KDM1A (0.53) | KDM1AMAOAMAOBRCOR1KDM1B | |
| SCHEMBL22334919 | 0.87 | KDM1A (0.58) | KDM1AMAOAMAOBRCOR1PTPN1 | |
| SCHEMBL22335073 | 0.85 | KDM1A (0.71) | KDM1AMAOAMAOBRCOR1KDM1B | |
| SCHEMBL22335099 | 0.85 | KDM1A (0.71) | KDM1AMAOAMAOBRCOR1KDM1B | |
| SCHEMBL22334901 | 0.84 | KDM1A (0.65) | KDM1AMAOAMAOBRCOR1KDM1B | |
| SCHEMBL22335097 | 0.84 | KDM1A (0.80) | KDM1AMAOAMAOBRCOR1KDM1B | |
| SCHEMBL22334929 | 0.83 | KMT2A (0.62) | DEGS1NR1H4 | |
| SCHEMBL22335158 | 0.82 | GAA (0.58) | KDM1AMAOAMAOBRCOR1KDM1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2928457-B1 | CYCLOPROPYLAMINE DERIVATIVES USEFUL AS INHIBITORS OF HISTONE DEMETHYLASES KDM1A | ST EUROPEO DI ONCOLOGIA S R L (IT) | 2020-08-12 | — | — | EP | disclosed |