Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC25B | P30305 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | GFER | P55789 | 2/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | THRB | P10828 | 4/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 2/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22335212 | 0.85 | CDC25B (0.46) | CDC25BLMNAKDM4EGFERMAPT | |
| SCHEMBL13688528 | 0.84 | IKBKB (0.56) | CDC25BLMNAKDM4EKMT2AGFER | |
| SCHEMBL5248866 | 0.84 | KDM4E (0.48) | CDC25BLMNAKDM4EMAPTTDP1 | |
| SCHEMBL265109 | 0.84 | KDM4E (0.65) | CDC25BLMNAKDM4EKMT2AGFER | |
| SCHEMBL29593435 | 0.84 | KDM4E (0.65) | CDC25BLMNAKDM4EKMT2AGFER | |
| SCHEMBL13522728 | 0.83 | CDC25B (0.49) | CDC25BLMNAKDM4EKMT2AGFER | |
| SCHEMBL11542659 | 0.82 | KDM4E (0.63) | CDC25BLMNAKDM4EKMT2AGFER | |
| SCHEMBL18829004 | 0.80 | CDC25B (0.46) | CDC25BLMNAKDM4EKMT2AGFER | |
| SCHEMBL5707615 | 0.78 | CDC25B (0.52) | CDC25BLMNAKDM4EKMT2AGFER | |
| SCHEMBL18828998 | 0.76 | CDC25B (0.42) | CDC25BLMNAKDM4EKMT2AGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3134408-B1 | FACTOR XIa INHIBITORS | MERCK SHARP & DOHME (US) | 2020-08-12 | — | — | EP | disclosed |