Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | KDR | P35968 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.43 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14949997 | 0.89 | SMN1; SMN2 (0.53) | SMN1; SMN2MEN1KMT2AALDH1A1NPC1 | |
| SCHEMBL22339755 | 0.87 | NPC1 (0.54) | HRH3SMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL10067677 | 0.86 | RXFP1 (0.54) | SMN1; SMN2KMT2ALMNATSHRPTPN1 | |
| SCHEMBL14239759 | 0.86 | KDR (0.51) | SMN1; SMN2ALDH1A1NPC1LMNAKDR | |
| SCHEMBL22341765 | 0.84 | PTPN1 (0.44) | HRH3SMN1; SMN2ALDH1A1NPC1KDR | |
| SCHEMBL18804907 | 0.83 | KCNK3 (0.54) | SMN1; SMN2MEN1KMT2AALDH1A1NPC1 | |
| SCHEMBL22339741 | 0.82 | KDR (0.50) | SMN1; SMN2NPC1LMNAKDRMCHR1 | |
| SCHEMBL9951429 | 0.82 | RXFP1 (0.49) | SMN1; SMN2MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL31376514 | 0.82 | RXFP1 (0.49) | SMN1; SMN2MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL29677914 | 0.82 | RXFP1 (0.49) | SMN1; SMN2MEN1KMT2AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220127232-A1 | HISTONE ACETYLTRANSFERASE MODULATORS AND COMPOSITIONS AND USES THEREOF | APPIA PHARMACEUTICALS LLC | 2022-04-28 | — | — | US | disclosed |
| WO-2020163731-A1 | HISTONE ACETYLTRANSFERASE MODULATORS AND COMPOSITIONS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2020-08-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220127232-A1 | HISTONE ACETYLTRANSFERASE MODULATORS AND COMPOSITIONS AND USES THEREOF | EP300, KAT2A, NAA40 | HRH3 455/4885SMN1; SMN2 769/4885MEN1 2627/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.