Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 6/20 | 0.44 |
| ▸ | PPARG | P37231 | 3/20 | 0.41 |
| ▸ | PPARA | Q07869 | 3/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22340277 | 0.93 | PPARD (0.45) | PPARDPPARGPPARAALDH1A1HPGD | |
| SCHEMBL24474598 | 0.92 | PPARD (0.46) | PPARDPPARGPPARAMAPK14ALDH1A1 | |
| SCHEMBL22340278 | 0.91 | PPARD (0.51) | PPARDPPARGPPARAALDH1A1HPGD | |
| Mavodelpar SCHEMBL1746569 | 0.91 | PPARD (0.55) | PPARDPPARGPPARAMAPK14 | |
| Mavodelpar SCHEMBL1746564 | 0.91 | PPARD (0.55) | PPARDPPARGPPARAMAPK14 | |
| Mavodelpar SCHEMBL1746567 | 0.91 | PPARD (0.55) | PPARDPPARGPPARAMAPK14 | |
| Mavodelpar SCHEMBL22323854 | 0.90 | PPARD (0.54) | PPARDPPARGPPARAMAPK14 | |
| Mavodelpar SCHEMBL18197414 | 0.90 | PPARD (0.54) | PPARDPPARGPPARAMAPK14 | |
| Mavodelpar SCHEMBL18197418 | 0.90 | PPARD (0.54) | PPARDPPARGPPARAMAPK14 | |
| Mavodelpar SCHEMBL18197415 | 0.90 | PPARD (0.47) | PPARDPPARGPPARAMAPK14ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021055725-A1 | USE OF A PPAR-DELTA AGONIST IN THE TREATMENT OF KIDNEY DISEASE | RENEO PHARMACEUTICALS, INC. (US) | 2021-03-25 | — | — | WO | disclosed |
| WO-2020163240-A1 | USE OF A PPAR-DELTA AGONIST IN THE TREATMENT OF FATTY ACID OXIDATION DISORDERS (FAOD) | RENEO PHARMACEUTICALS, INC. (US) | 2020-08-13 | — | — | WO | disclosed |