Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | PKM | P14618 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23424660 | 0.84 | NPC1 (0.54) | NPC1RAB9APKMKMT2ACYP11B2 | |
| SCHEMBL28360818 | 0.79 | KMT2A (0.59) | NPC1RAB9APKMKMT2ACYP11B2 | |
| SCHEMBL2723393 | 0.78 | NPC1 (0.50) | NPC1RAB9APKMKMT2ACYP11B2 | |
| SCHEMBL16865781 | 0.77 | NPC1 (0.61) | NPC1RAB9APKMKMT2ACYP11B2 | |
| SCHEMBL22997125 | 0.76 | NPC1 (0.61) | NPC1RAB9APKMKMT2ACYP11B2 | |
| SCHEMBL28636069 | 0.76 | NPC1 (0.59) | NPC1RAB9APKMKMT2ACYP11B2 | |
| SCHEMBL28283576 | 0.76 | NPC1 (0.59) | NPC1RAB9APKMKMT2ACYP11B2 | |
| SCHEMBL22340589 | 0.76 | NPC1 (0.47) | NPC1RAB9ATP53SMN1; SMN2GAA | |
| SCHEMBL22291931 | 0.75 | NPC1 (0.68) | NPC1RAB9APKMKMT2ACYP11B2 | |
| SCHEMBL10067181 | 0.75 | NPC1 (0.54) | NPC1RAB9APKMKMT2ACYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020163236-A1 | TREATING LONG QT SYNDROME | THE GENERAL HOSPITAL CORPORATION (US) | 2020-08-13 | — | — | WO | disclosed |