SCHEMBL22341828

SCHEMBL22341828

COc1cnc2c(-c3nc4cc(F)c(O[C@@H](C)[C@@H](C)N(C(=O)O)c5cnc(C)nc5)nc4s3)cc(Cl)cc2c1

nearest known ligand 0.47

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
F2RL3 Q96RI0 20/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22341849 0.93 F2RL3 (0.40) F2RL3
SCHEMBL22341901 0.92 F2RL3 (0.40) F2RL3
SCHEMBL22341837 0.92 F2RL3 (0.40) F2RL3
SCHEMBL22341824 0.90 F2RL3 (0.50) F2RL3
SCHEMBL22341787 0.90 F2RL3 (0.41) F2RL3
SCHEMBL22341900 0.90 F2RL3 (0.41) F2RL3
SCHEMBL22341841 0.88 F2RL3 (0.47) F2RL3
SCHEMBL22341871 0.88 F2RL3 (0.40) F2RL3
SCHEMBL23405335 0.88 F2RL3 (0.58) F2RL3
SCHEMBL23405334 0.88 F2RL3 (0.58) F2RL3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3484878-B1 BICYCLIC HETEROARYL SUBSTITUTED COMPOUNDS BRISTOL MYERS SQUIBB CO (US) 2020-08-19 EP claimed