SCHEMBL22341835

SCHEMBL22341835

CCOc1cnc2c(-c3nc4cc(F)c(O[C@@H](C)[C@@H](C)N(C(=O)O)c5cnc(C)nc5)cc4s3)cc(C)cc2c1

nearest known ligand 0.44

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
F2RL3 Q96RI0 20/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22341833 0.93 F2RL3 (0.51) F2RL3
SCHEMBL21379613 0.93 F2RL3 (0.49) F2RL3
SCHEMBL21379612 0.93 F2RL3 (0.49) F2RL3
SCHEMBL22341844 0.92 F2RL3 (0.43) F2RL3
SCHEMBL22342073 0.89 F2RL3 (0.56) F2RL3
SCHEMBL22342069 0.89 F2RL3 (0.56) F2RL3
SCHEMBL22341817 0.88 F2RL3 (0.51) F2RL3
SCHEMBL22341834 0.88 F2RL3 (0.50) F2RL3
SCHEMBL22341992 0.86 F2RL3 (0.49) F2RL3
SCHEMBL21379584 0.86 F2RL3 (0.47) F2RL3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3484878-B1 BICYCLIC HETEROARYL SUBSTITUTED COMPOUNDS BRISTOL MYERS SQUIBB CO (US) 2020-08-19 EP claimed