SCHEMBL22341845

SCHEMBL22341845

C#COc1cc2sc(-c3cc(C)cc4nc(OC)cnc34)nc2c(Cl)c1F

nearest known ligand 0.53

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
F2RL3 Q96RI0 19/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30187579 0.92 F2RL3 (0.59) F2RL3
SCHEMBL21395770 0.92 F2RL3 (0.59) F2RL3
SCHEMBL22341906 0.91 F2RL3 (0.54) F2RL3
SCHEMBL22341894 0.88 F2RL3 (0.45) F2RL3
SCHEMBL22341880 0.86 F2RL3 (0.54) F2RL3
SCHEMBL30189903 0.85 F2RL3 (0.53) F2RL3
SCHEMBL19783719 0.85 F2RL3 (0.52) F2RL3
SCHEMBL21379341 0.85 F2RL3 (0.52) F2RL3
SCHEMBL30187594 0.85 F2RL3 (0.52) F2RL3
SCHEMBL19783518 0.85 F2RL3 (0.53) F2RL3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3484878-B1 BICYCLIC HETEROARYL SUBSTITUTED COMPOUNDS BRISTOL MYERS SQUIBB CO (US) 2020-08-19 EP claimed