Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 19/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 14/20 | 0.54 |
| ▸ | PDE4A | P27815 | 13/20 | 0.54 |
| ▸ | PDE4C | Q08493 | 13/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL729245 | 0.85 | PDE4B (0.58) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL14924574 | 0.80 | PDE4B (0.52) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL730520 | 0.79 | PDE4B (0.68) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL3676851 | 0.73 | PDE4B (0.65) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL728829 | 0.72 | PDE4B (0.52) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL730996 | 0.72 | PDE4B (0.61) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL3681398 | 0.71 | PDE4B (0.71) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL3671130 | 0.71 | PDE4B (0.70) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL3676425 | 0.71 | PDE4B (0.70) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL6586279 | 0.70 | PDE4B (1.00) | PDE4BPDE4DPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2467376-A1 | BICYCLIC HETEROARYL INHIBITORS OF PDE4 | Kalypsys, Inc. (US) | 2012-06-27 | — | — | EP | disclosed |
| WO-2011093924-A1 | BICYCLIC HETEROARYL INHIBITORS OF PDE4 | KALYPSYS, INC (US) | 2011-08-04 | — | — | WO | disclosed |
| EP-2037924-A2 | BICYCLIC HETEROARYL INHIBITORS OF PDE4 | Govek, Steven P. (US) | 2009-03-25 | — | — | EP | disclosed |
| WO-2008006050-A2 | BICYCLIC HETEROARYL INHIBITORS OF PDE4 | GOVEK STEVEN P (US) | 2008-01-10 | — | — | WO | disclosed |