Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 16/20 | 0.81 |
| ▸ | LCK | P06239 | 14/20 | 0.81 |
| ▸ | BTK | Q06187 | 16/20 | 0.72 |
| ▸ | EGFR | P00533 | 9/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22346794 | 1.00 | JAK3 (0.81) | JAK3LCKBTKEGFR | |
| SCHEMBL22346476 | 0.95 | JAK3 (0.82) | JAK3LCKBTKEGFR | |
| SCHEMBL22346475 | 0.95 | JAK3 (0.82) | JAK3LCKBTKEGFR | |
| SCHEMBL22359003 | 0.92 | JAK3 (0.79) | JAK3LCKBTKEGFR | |
| SCHEMBL22346730 | 0.90 | JAK3 (0.87) | JAK3LCKBTKEGFR | |
| SCHEMBL22358976 | 0.90 | JAK3 (0.87) | JAK3LCKBTKEGFR | |
| SCHEMBL16764007 | 0.89 | JAK3 (1.00) | JAK3LCKBTKEGFR | |
| SCHEMBL16764004 | 0.89 | JAK3 (1.00) | JAK3LCKBTKEGFR | |
| SCHEMBL22346856 | 0.89 | JAK3 (0.71) | JAK3LCKBTKEGFR | |
| SCHEMBL22346854 | 0.89 | JAK3 (0.71) | JAK3LCKBTKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3924350-A1 | BIFUNCTIONAL COMPOUNDS FOR DEGRADING BTK VIA UBIQUITIN PROTEOSOME PATHWAY | Nurix Therapeutics, Inc. (US) | 2021-12-22 | — | — | EP | disclosed |
| WO-2020167518-A1 | BIFUNCTIONAL COMPOUNDS FOR DEGRADING BTK VIA UBIQUITIN PROTEOSOME PATHWAY | NURIX THERAPEUTICS, INC. (US) | 2020-08-20 | — | — | WO | disclosed |