Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 20/20 | 0.52 |
| ▸ | NR1I2 | O75469 | 7/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 7/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 7/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22348042 | 0.96 | NR1H4 (0.49) | NR1H4NR1I2CYP2C9CYP2C19 | |
| SCHEMBL22347990 | 0.88 | NR1H4 (0.50) | NR1H4CYP2C9 | |
| SCHEMBL22347795 | 0.84 | NR1H4 (0.53) | NR1H4NR1I2CYP2C9CYP2C19 | |
| SCHEMBL22348156 | 0.81 | GLA (0.43) | NR1H4CYP2C9CYP2C19 | |
| SCHEMBL22348141 | 0.81 | NR1H4 (0.49) | NR1H4NR1I2CYP2C9CYP2C19 | |
| SCHEMBL22348396 | 0.78 | NR1H4 (0.52) | NR1H4NR1I2CYP2C9CYP2C19 | |
| SCHEMBL22348637 | 0.76 | NR1H4 (0.49) | NR1H4CYP2C9 | |
| SCHEMBL22348176 | 0.76 | NR1H4 (0.83) | NR1H4NR1I2CYP2C9CYP2C19 | |
| SCHEMBL22350432 | 0.76 | NR1H4 (0.65) | NR1H4NR1I2CYP2C9CYP2C19 | |
| SCHEMBL29901052 | 0.76 | NR1H4 (0.65) | NR1H4NR1I2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3924329-A2 | SUBSTITUTED AMIDE COMPOUNDS USEFUL AS FARNESOID X RECEPTOR MODULATORS | Bristol-Myers Squibb Company (US) | 2021-12-22 | — | — | EP | claimed |
| WO-2020168152-A2 | SUBSTITUTED AMIDE COMPOUNDS USEFUL AS FARNESOID X RECEPTOR MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2020-08-20 | — | — | WO | claimed |
| EP-3924329-A2 | SUBSTITUTED AMIDE COMPOUNDS USEFUL AS FARNESOID X RECEPTOR MODULATORS | Bristol-Myers Squibb Company (US) | 2021-12-22 | — | — | EP | disclosed |
| WO-2020168152-A2 | SUBSTITUTED AMIDE COMPOUNDS USEFUL AS FARNESOID X RECEPTOR MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2020-08-20 | — | — | WO | disclosed |