Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ5 | P48544 | 7/20 | 0.46 |
| ▸ | KCNJ3 | P48549 | 7/20 | 0.46 |
| ▸ | KCNJ6 | P48051 | 3/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | PRKX | P51817 | 1/20 | 0.41 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.41 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.41 |
| ▸ | NR2E1 | Q9Y466 | 3/20 | 0.41 |
| ▸ | P2RX4 | Q99571 | 4/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.39 |
| ▸ | RORA | P35398 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | ANO1 | Q5XXA6 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22353223 | 0.88 | KCNJ5 (0.46) | KCNJ5KCNJ3KCNJ6CLK2PRKX | |
| SCHEMBL22353190 | 0.85 | KCNJ5 (0.53) | KCNJ5KCNJ3KCNJ6CLK2PRKX | |
| SCHEMBL22894294 | 0.85 | P2RX4 (0.46) | KCNJ5KCNJ3KCNJ6CLK2PRKX | |
| SCHEMBL29717058 | 0.84 | P2RX4 (0.54) | P2RX4 | |
| SCHEMBL19552636 | 0.84 | P2RX4 (0.54) | P2RX4 | |
| SCHEMBL22894246 | 0.84 | P2RX4 (0.43) | KCNJ5KCNJ3KCNJ6CLK2PRKX | |
| SCHEMBL22353191 | 0.84 | P2RX4 (0.44) | KCNJ5KCNJ3KCNJ6CLK2PRKX | |
| SCHEMBL22894234 | 0.82 | P2RX4 (0.46) | KCNJ5KCNJ3KCNJ6CLK2PRKX | |
| SCHEMBL19576918 | 0.80 | NPY2R (0.43) | KCNJ5KCNJ3KCNJ6CLK2PRKX | |
| SCHEMBL22353131 | 0.79 | NR2E1 (0.48) | KCNJ5KCNJ3NR2E1P2RX4ANO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3458443-B1 | AROMATIC SULFONAMIDE DERIVATIVES | Bayer Pharma AG (DE) | 2020-08-19 | — | — | EP | disclosed |