Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Raloxifene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 known ✓ | P03372 | 19/20 | 0.88 |
| ▸ | ESR2 known ✓ | Q92731 | 17/20 | 0.88 |
| ▸ | MEN1 | O00255 | 2/20 | 0.88 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.88 |
| ▸ | LMNA | P02545 | 2/20 | 0.88 |
| ▸ | TP53 | P04637 | 2/20 | 0.88 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.88 |
| ▸ | MAPT | P10636 | 2/20 | 0.88 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.88 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.88 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.88 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.88 |
| ▸ | PLD2 | O14939 | 1/20 | 0.88 |
| ▸ | KDM1A | O60341 | 1/20 | 0.88 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.88 |
| ▸ | USP2 | O75604 | 1/20 | 0.88 |
| ▸ | C5 | P01031 | 1/20 | 0.88 |
| ▸ | FYN | P06241 | 1/20 | 0.88 |
| ▸ | PGR | P06401 | 1/20 | 0.88 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.88 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Raloxifene SCHEMBL2235454 | 1.00 | ESR1 (0.88) | ESR1ESR2MEN1ALDH1A1LMNA | |
| Raloxifene SCHEMBL2235458 | 1.00 | ESR1 (0.88) | ESR1ESR2MEN1ALDH1A1LMNA | |
| Raloxifene SCHEMBL2235441 | 1.00 | ESR1 (0.88) | ESR1ESR2MEN1ALDH1A1LMNA | |
| Raloxifene SCHEMBL2234855 | 0.99 | ESR1 (0.90) | ESR1ESR2MEN1ALDH1A1LMNA | |
| Raloxifene SCHEMBL1751808 | 0.96 | ESR1 (0.93) | ESR1ESR2MEN1ALDH1A1LMNA | |
| Raloxifene SCHEMBL973873 | 0.95 | ESR1 (0.98) | ESR1ESR2MEN1ALDH1A1LMNA | |
| Raloxifene SCHEMBL2733917 | 0.94 | ESR1 (0.90) | ESR1ESR2MEN1ALDH1A1LMNA | |
| Raloxifene SCHEMBL975023 | 0.94 | ESR1 (0.98) | ESR1ESR2MEN1ALDH1A1LMNA | |
| Raloxifene SCHEMBL3162158 | 0.94 | ESR1 (1.00) | ESR1ESR2MEN1ALDH1A1LMNA | |
| Raloxifene SCHEMBL9145135 | 0.94 | ESR1 (1.00) | ESR1ESR2MEN1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011099942-A1 | NEW ADDITION SALTS OF RALOXIFENE, PROCESS FOR THE PREPARATION THEREOF AND USE THEREOF IN THERAPY | SILVERSTONE PHARMA (LI) | 2011-08-18 | — | — | WO | claimed |
| WO-2011099942-A1 | NEW ADDITION SALTS OF RALOXIFENE, PROCESS FOR THE PREPARATION THEREOF AND USE THEREOF IN THERAPY | SILVERSTONE PHARMA (LI) | 2011-08-18 | — | — | WO | disclosed |