Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | FYN | P06241 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | C5 | P01031 | 1/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.42 |
| ▸ | MYC | P01106 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18089590 | 0.95 | KDM4E (0.54) | KDM4EKMT2ALCKFYNNPC1 | |
| SCHEMBL4377156 | 0.92 | KDM4E (0.51) | KDM4EKMT2ALCKFYNNPC1 | |
| SCHEMBL3324427 | 0.92 | KDM4E (0.51) | KDM4EKMT2ALCKFYNNPC1 | |
| SCHEMBL13257727 | 0.92 | KDM4E (0.51) | KDM4EKMT2ALCKFYNNPC1 | |
| SCHEMBL13299069 | 0.92 | KDM4E (0.51) | KDM4EKMT2ALCKFYNNPC1 | |
| SCHEMBL23489015 | 0.91 | KDM4E (0.53) | KDM4EKMT2ALCKFYNALDH1A1 | |
| SCHEMBL29597889 | 0.91 | KDM4E (0.53) | KDM4EKMT2ALCKFYNNPC1 | |
| SCHEMBL2330272 | 0.91 | KDM4E (0.53) | KDM4EKMT2ALCKFYNNPC1 | |
| SCHEMBL3842703 | 0.89 | KDM4E (0.51) | KDM4EKMT2ALCKFYNNPC1 | |
| SCHEMBL19426390 | 0.89 | KDM4E (0.48) | KDM4ELCKFYNNPC1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8487092-B2 | Pyrrolobenzodiazepines | SPIROGEN DEVELOPMENTS SARL (CH) | 2013-07-16 | — | — | US | disclosed |
| US-8487092-B2 | Pyrrolobenzodiazepines | SPIROGEN DEVELOPMENTS SARL (CH) | 2013-07-16 | — | — | US | disclosed |
| EP-2350098-B1 | PYRROLOBENZODIAZEPINES | SPIROGEN SARL (CH) | 2013-05-15 | — | — | EP | disclosed |
| EP-2350098-B1 | PYRROLOBENZODIAZEPINES | SPIROGEN SARL (CH) | 2013-05-15 | — | — | EP | disclosed |
| US-20110201803-A1 | PYRROLOBENZODIAZEPINES | SPIROGEN LIMITED (GB) | 2011-08-18 | — | — | US | disclosed |
| US-20110201803-A1 | PYRROLOBENZODIAZEPINES | SPIROGEN LIMITED (GB) | 2011-08-18 | — | — | US | disclosed |
| EP-2350098-A1 | PYRROLOBENZODIAZEPINES | Spirogen Limited (GB) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010043877-A1 | PYRROLOBENZODIAZEPINES | SPIROGEN LIMITED (GB) | 2010-04-22 | — | — | WO | disclosed |
| WO-2010043877-A1 | PYRROLOBENZODIAZEPINES | SPIROGEN LIMITED (GB) | 2010-04-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110201803-A1 | PYRROLOBENZODIAZEPINES | HCRTR2, HCRTR1, CBR3 | KDM4E 3339/4885KMT2A 1140/4885LCK 3232/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.