Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 15/20 | 0.61 |
| ▸ | NMBR | P28336 | 1/20 | 0.47 |
| ▸ | CPB1 | P15086 | 2/20 | 0.38 |
| ▸ | CPB2 | Q96IY4 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ESRRB | O95718 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2000374 | 1.00 | SIRT2 (0.61) | SIRT2NMBRCPB1CPB2ALDH1A1 | |
| SCHEMBL27015285 | 0.87 | SIRT2 (0.52) | SIRT2NMBRCPB1CPB2 | |
| SCHEMBL1997674 | 0.87 | SIRT2 (0.52) | SIRT2NMBRCPB1CPB2 | |
| SCHEMBL522051 | 0.87 | SIRT2 (0.60) | SIRT2NMBRCPB1CPB2 | |
| SCHEMBL10026712 | 0.87 | SIRT2 (0.60) | SIRT2NMBRCPB1CPB2 | |
| SCHEMBL1999739 | 0.87 | SIRT2 (0.60) | SIRT2NMBRCPB1CPB2 | |
| SCHEMBL523065 | 0.87 | SIRT2 (0.60) | SIRT2NMBRCPB1CPB2 | |
| SCHEMBL18715386 | 0.86 | SIRT2 (0.67) | SIRT2NMBRALDH1A1 | |
| Hydrochloric Acid SCHEMBL522050 | 0.86 | SIRT2 (0.59) | SIRT2NMBRCPB1CPB2 | |
| Hydrochloric Acid SCHEMBL522052 | 0.86 | SIRT2 (0.59) | SIRT2NMBRCPB1CPB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3696171-A1 | MODULATORS OF PHARMACOKINETIC PROPERTIES OF THERAPEUTICS | Gilead Sciences, Inc. (US) | 2020-08-19 | — | — | EP | disclosed |