Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 16/20 | 0.61 |
| ▸ | LCK | P06239 | 14/20 | 0.61 |
| ▸ | BTK | Q06187 | 14/20 | 0.59 |
| ▸ | EGFR | P00533 | 9/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22358884 | 0.91 | JAK3 (0.76) | JAK3LCKBTKEGFR | |
| SCHEMBL22359002 | 0.89 | JAK3 (0.75) | JAK3LCKBTKEGFR | |
| SCHEMBL22358867 | 0.88 | JAK3 (0.66) | JAK3LCKBTKEGFR | |
| SCHEMBL22359248 | 0.84 | JAK3 (0.81) | JAK3LCKBTKEGFR | |
| SCHEMBL22358872 | 0.80 | BTK (0.59) | JAK3LCKBTKEGFR | |
| SCHEMBL16763738 | 0.79 | JAK3 (0.82) | JAK3LCKBTKEGFR | |
| SCHEMBL16763736 | 0.79 | JAK3 (0.82) | JAK3LCKBTKEGFR | |
| SCHEMBL22359001 | 0.79 | JAK3 (0.79) | JAK3LCKBTKEGFR | |
| SCHEMBL22358893 | 0.79 | BTK (0.61) | JAK3LCKBTKEGFR | |
| SCHEMBL22346476 | 0.78 | JAK3 (0.82) | JAK3LCKBTKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020167518-A1 | BIFUNCTIONAL COMPOUNDS FOR DEGRADING BTK VIA UBIQUITIN PROTEOSOME PATHWAY | NURIX THERAPEUTICS, INC. (US) | 2020-08-20 | — | — | WO | disclosed |