Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.33 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SCN1A | P35498 | 1/20 | 0.33 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.33 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PDE9A | O76083 | 1/20 | 0.31 |
| ▸ | PDE1A | P54750 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21161631 | 0.90 | SYK (0.35) | SYKRECQLCYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL2667103 | 0.90 | SYK (0.35) | SYKRECQLCYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL21375528 | 0.84 | RECQL (0.37) | RECQLCYP1A2CYP2C19ALDH1A1CYP2C9 | |
| SCHEMBL20158888 | 0.84 | MEN1 (0.40) | RECQLCYP1A2CYP2C19ALDH1A1CYP2C9 | |
| SCHEMBL3786037 | 0.83 | RECQL (0.35) | RECQLCYP1A2CYP2C19ALDH1A1CYP2C9 | |
| SCHEMBL19380327 | 0.83 | MEN1 (0.42) | RECQLCYP1A2CYP2C19ALDH1A1CYP2C9 | |
| SCHEMBL16900593 | 0.83 | RECQL (0.36) | RECQLCYP1A2CYP2C19ALDH1A1CYP2C9 | |
| SCHEMBL22143595 | 0.79 | CYP1A2 (0.39) | RECQLCYP1A2CYP2C19ALDH1A1CYP2C9 | |
| SCHEMBL20018195 | 0.78 | CYP1A2 (0.39) | RECQLCYP1A2CYP2C19ALDH1A1CYP2C9 | |
| SCHEMBL21646966 | 0.77 | RECQL (0.37) | RECQLCYP1A2CYP2C19ALDH1A1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3423443-B1 | CYANO-SUBSTITUTED INDOLE COMPOUNDS AND USES THEREOF AS LSD1 INHIBITORS | NOVARTIS AG (CH) | 2020-08-19 | — | — | EP | disclosed |