Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | TEK | Q02763 | 2/20 | 0.39 |
| ▸ | DPP4 | P27487 | 2/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.38 |
| ▸ | IDH1 | O75874 | 1/20 | 0.36 |
| ▸ | CD74 | P04233 | 1/20 | 0.36 |
| ▸ | MIF | P14174 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | ESRRG | P62508 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22360791 | 0.84 | LRRK2 (0.39) | MEN1KMT2ANPC1RAB9AL3MBTL1 | |
| SCHEMBL22360849 | 0.84 | MEN1 (0.38) | MEN1KMT2ANPC1RAB9AL3MBTL1 | |
| SCHEMBL22360898 | 0.80 | MEN1 (0.36) | MEN1KMT2ANPC1RAB9AL3MBTL1 | |
| SCHEMBL22185240 | 0.77 | NPC1 (0.46) | BRD4MEN1KMT2ANPC1RAB9A | |
| SCHEMBL17091027 | 0.76 | EPHB4 (0.43) | BRD4MEN1KMT2ANPC1RAB9A | |
| SCHEMBL17201333 | 0.76 | EPHB4 (0.43) | BRD4MEN1KMT2ANPC1RAB9A | |
| SCHEMBL21873515 | 0.76 | EPHB4 (0.46) | BRD4MEN1KMT2ANPC1RAB9A | |
| SCHEMBL15729597 | 0.76 | HRH3 (0.45) | BRD4MEN1KMT2ANPC1RAB9A | |
| SCHEMBL1337524 | 0.74 | IDO1 (0.41) | — | |
| SCHEMBL23329321 | 0.74 | ESRRG (0.46) | NPC1RAB9AL3MBTL1IDH1ESRRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020168172-A1 | CONJUGATE COMPOUNDS FOR THE DEGRADATION OF RAF | ZAMBONI CHEM SOLUTIONS INC. (CA) | 2020-08-20 | — | — | WO | disclosed |