Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 19/20 | 0.92 |
| ▸ | BRAF | P15056 | 10/20 | 0.92 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.79 |
| ▸ | ARAF | P10398 | 1/20 | 0.79 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.79 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16121752 | 0.96 | RAF1 (1.00) | RAF1BRAFPDGFRBARAFDDR1 | |
| SCHEMBL16094874 | 0.92 | RAF1 (0.89) | RAF1BRAFPDGFRBARAFDDR1 | |
| SCHEMBL29610663 | 0.92 | RAF1 (0.89) | RAF1BRAFPDGFRBARAFDDR1 | |
| SCHEMBL16121357 | 0.91 | RAF1 (1.00) | RAF1BRAFPDGFRBARAFDDR1 | |
| SCHEMBL17523467 | 0.91 | BRAF (1.00) | RAF1BRAFPDGFRBARAFDDR1 | |
| SCHEMBL16099724 | 0.90 | RAF1 (1.00) | RAF1BRAFPDGFRBARAFDDR1 | |
| SCHEMBL22360882 | 0.90 | RAF1 (0.86) | RAF1BRAFPDGFRBARAFDDR1 | |
| SCHEMBL24029285 | 0.89 | RAF1 (0.84) | RAF1BRAFPDGFRBARAFDDR1 | |
| SCHEMBL16121843 | 0.89 | RAF1 (1.00) | RAF1BRAFPDGFRBARAFDDR1 | |
| Naporafenib SCHEMBL16094629 | 0.88 | RAF1 (1.00) | RAF1BRAFPDGFRBARAFDDR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081469-A1 | INHIBITORS OF RAF KINASES | KINNATE BIOPHARMA INC. (US) | 2022-04-21 | — | — | WO | disclosed |
| WO-2020168172-A1 | CONJUGATE COMPOUNDS FOR THE DEGRADATION OF RAF | ZAMBONI CHEM SOLUTIONS INC. (CA) | 2020-08-20 | — | — | WO | disclosed |