SCHEMBL22360968

SCHEMBL22360968

CC1CC(=O)Nc2cccc(C(=O)Nc3cccc(-c4cnco4)c3)c2O1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CREBBP Q92793 18/20 1.00
BRD4 O60885 16/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17680753 1.00 CREBBP (1.00) CREBBPBRD4
SCHEMBL17680591 1.00 CREBBP (1.00) CREBBPBRD4
SCHEMBL17680680 0.90 CREBBP (0.82) CREBBPBRD4
SCHEMBL17680615 0.84 CREBBP (1.00) CREBBPBRD4
SCHEMBL17680684 0.83 CREBBP (0.71) CREBBPBRD4
SCHEMBL17680979 0.81 CREBBP (0.80) CREBBPBRD4
SCHEMBL17680595 0.81 CREBBP (1.00) CREBBPBRD4
SCHEMBL17673284 0.81 CREBBP (1.00) CREBBPBRD4
SCHEMBL17680681 0.81 CREBBP (1.00) CREBBPBRD4
SCHEMBL22368807 0.79 CREBBP (0.73) CREBBPBRD4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3204360-B1 THERAPEUTIC COMPOUNDS AND USES THEREOF GENENTECH INC (US) 2020-08-26 EP disclosed