SCHEMBL22360978

SCHEMBL22360978

CC(C)Oc1cccc(NC(=O)c2cccc3c2OC(C)CC(=O)N3)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CREBBP Q92793 19/20 1.00
BRD4 O60885 17/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17680749 1.00 CREBBP (1.00) CREBBPBRD4
SCHEMBL17680598 1.00 CREBBP (1.00) CREBBPBRD4
SCHEMBL22368805 0.92 CREBBP (0.84) CREBBPBRD4
SCHEMBL17680979 0.86 CREBBP (0.80) CREBBPBRD4
SCHEMBL17673284 0.85 CREBBP (1.00) CREBBPBRD4
SCHEMBL17680595 0.85 CREBBP (1.00) CREBBPBRD4
SCHEMBL17680681 0.85 CREBBP (1.00) CREBBPBRD4
SCHEMBL22369200 0.82 CREBBP (0.69) CREBBPBRD4
SCHEMBL22368674 0.81 CREBBP (0.83) CREBBPBRD4
SCHEMBL17680618 0.81 CREBBP (1.00) CREBBPBRD4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3204360-B1 THERAPEUTIC COMPOUNDS AND USES THEREOF GENENTECH INC (US) 2020-08-26 EP disclosed
EP-3204360-B1 THERAPEUTIC COMPOUNDS AND USES THEREOF GENENTECH INC (US) 2020-08-26 EP disclosed