Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 13/20 | 0.50 |
| ▸ | CCNA2 | P20248 | 11/20 | 0.50 |
| ▸ | CDK2 | P24941 | 11/20 | 0.50 |
| ▸ | CCNA1 | P78396 | 11/20 | 0.50 |
| ▸ | MTOR | P42345 | 3/20 | 0.43 |
| ▸ | RPTOR | Q8N122 | 3/20 | 0.43 |
| ▸ | MLST8 | Q9BVC4 | 3/20 | 0.43 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.43 |
| ▸ | STK10 | O94804 | 1/20 | 0.43 |
| ▸ | LATS1 | O95835 | 1/20 | 0.43 |
| ▸ | PAK4 | O96013 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | NQO2 | P16083 | 1/20 | 0.43 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.43 |
| ▸ | MARK3 | P27448 | 1/20 | 0.43 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.43 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.43 |
| ▸ | PRKCI | P41743 | 1/20 | 0.43 |
| ▸ | PSMC4 | P43686 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7878863 | 0.89 | CHEK1 (0.57) | CHEK1CCNA2CDK2CCNA1MTOR | |
| SCHEMBL7878999 | 0.89 | CHEK1 (0.52) | CHEK1CCNA2CDK2CCNA1MTOR | |
| SCHEMBL595514 | 0.89 | CHEK1 (0.52) | CHEK1CCNA2CDK2CCNA1MTOR | |
| SCHEMBL596322 | 0.89 | CHEK1 (0.52) | CHEK1CCNA2CDK2CCNA1MTOR | |
| SCHEMBL6891867 | 0.88 | CHEK1 (0.49) | CHEK1CCNA2CDK2CCNA1MTOR | |
| Bicarbonate SCHEMBL17836471 | 0.88 | CHEK1 (0.49) | CHEK1CCNA2CDK2CCNA1MTOR | |
| SCHEMBL6893495 | 0.88 | CHEK1 (0.49) | CHEK1CCNA2CDK2CCNA1MTOR | |
| SCHEMBL10235075 | 0.88 | CHEK1 (0.63) | CHEK1CCNA2CDK2CCNA1MTOR | |
| Bicarbonate SCHEMBL17836379 | 0.87 | CHEK1 (0.49) | CHEK1CCNA2CDK2CCNA1MTOR | |
| Bicarbonate SCHEMBL17836451 | 0.87 | CHEK1 (0.49) | CHEK1CCNA2CDK2CCNA1MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012027236-A1 | NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | SCHERING CORPORATION (US) | 2012-03-01 | — | — | WO | disclosed |