Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | GALR2 | O43603 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | XBP1 | P17861 | 1/20 | 0.40 |
| ▸ | CCR6 | P51684 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2320088 | 0.83 | MAPT (0.43) | SMN1; SMN2ALDH1A1GALR2MITFLMNA | |
| SCHEMBL13468095 | 0.83 | GRIN2D (0.42) | SMN1; SMN2ALDH1A1POLBHPGDPDGFRB | |
| SCHEMBL22367846 | 0.83 | PDGFRB (0.39) | SMN1; SMN2ALDH1A1LMNAPOLBPDGFRB | |
| SCHEMBL7409820 | 0.82 | SMN1; SMN2 (0.40) | SMN1; SMN2ALDH1A1GALR2MITFLMNA | |
| SCHEMBL22367839 | 0.81 | GRIN2D (0.40) | SMN1; SMN2ALDH1A1LMNAPDGFRBFGFR1 | |
| SCHEMBL30350395 | 0.81 | GAA (0.38) | SMN1; SMN2ALDH1A1GALR2MITFLMNA | |
| SCHEMBL12869693 | 0.80 | SMN1; SMN2 (0.49) | SMN1; SMN2ALDH1A1POLBHPGDNPSR1 | |
| SCHEMBL31273385 | 0.78 | MAPT (0.42) | SMN1; SMN2ALDH1A1GALR2MITFLMNA | |
| SCHEMBL13088439 | 0.77 | SMN1; SMN2 (0.45) | SMN1; SMN2ALDH1A1GALR2MITFLMNA | |
| SCHEMBL2624006 | 0.76 | MAPT (0.43) | SMN1; SMN2ALDH1A1GALR2MITFLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111278814-B | Polycyclic amides as positive allosteric modulators of muscarinic M1 receptors | 苏文生命科学有限公司 | 2022-10-28 | — | — | CN | disclosed |
| US-11278530-B2 | Polycyclic amides as muscarinic M1 receptor positive allosteric modulators | SUVEN LIFE SCIENCES LIMITED (IN) | 2022-03-22 | — | — | US | disclosed |
| EP-3700895-B1 | POLYCYCLIC AMIDES AS MUSCARINIC M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | SUVEN LIFE SCIENCES LTD (IN) | 2021-09-22 | — | — | EP | disclosed |
| US-20200297703-A1 | POLYCYCLIC AMIDES AS MUSCARINIC M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | SUVEN LIFE SCIENCES LIMITED (CN) | 2020-09-24 | — | — | US | disclosed |
| EP-3700895-A1 | POLYCYCLIC AMIDES AS MUSCARINIC M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | Suven Life Sciences Limited (IN) | 2020-09-02 | — | — | EP | disclosed |
| CN-111278814-A | Polycyclic amides as positive allosteric modulators of the muscarinic M1 receptor | 苏文生命科学有限公司 | 2020-06-12 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200297703-A1 | POLYCYCLIC AMIDES AS MUSCARINIC M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | CHRM1, CHRM2, CHRM5 | SMN1; SMN2 3174/4885ALDH1A1 3793/4885GALR2 321/4885 |
| US-11278530-B2 | Polycyclic amides as muscarinic M1 receptor positive allosteric modulators | CHRM1, CHRM2, CHRM5 | SMN1; SMN2 3174/4885ALDH1A1 3793/4885GALR2 321/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.