Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.56 |
| ▸ | NR3C2 | P08235 | 5/20 | 0.56 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.56 |
| ▸ | HSD11B2 | P80365 | 2/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 7/20 | 0.55 |
| ▸ | LMNA | P02545 | 6/20 | 0.55 |
| ▸ | SERPINA6 | P08185 | 6/20 | 0.53 |
| ▸ | SHBG | P04278 | 6/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.53 |
| ▸ | BLM | P54132 | 3/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.53 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.53 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.53 |
| ▸ | THPO | P40225 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29504095 | 0.92 | SMN1; SMN2 (0.59) | SMN1; SMN2NR3C2HSD11B1HSD11B2HIF1A | |
| SCHEMBL20058429 | 0.81 | SMN1; SMN2 (0.67) | SMN1; SMN2NR3C2HSD11B1HSD11B2HIF1A | |
| SCHEMBL2508760 | 0.81 | SMN1; SMN2 (0.67) | SMN1; SMN2NR3C2HSD11B1HSD11B2HIF1A | |
| SCHEMBL13753020 | 0.81 | SMN1; SMN2 (0.67) | SMN1; SMN2NR3C2HSD11B1HSD11B2HIF1A | |
| SCHEMBL17906550 | 0.81 | SMN1; SMN2 (0.67) | SMN1; SMN2NR3C2HSD11B1HSD11B2HIF1A | |
| SCHEMBL23864218 | 0.81 | SMN1; SMN2 (0.67) | SMN1; SMN2NR3C2HSD11B1HSD11B2HIF1A | |
| SCHEMBL13176037 | 0.81 | SMN1; SMN2 (0.67) | SMN1; SMN2NR3C2HSD11B1HSD11B2HIF1A | |
| SCHEMBL17361261 | 0.81 | SMN1; SMN2 (0.67) | SMN1; SMN2NR3C2HSD11B1HSD11B2HIF1A | |
| SCHEMBL10301232 | 0.81 | SMN1; SMN2 (0.67) | SMN1; SMN2NR3C2HSD11B1HSD11B2HIF1A | |
| SCHEMBL14284911 | 0.81 | SMN1; SMN2 (0.67) | SMN1; SMN2NR3C2HSD11B1HSD11B2HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3171855-B1 | 11.BETA.-HYDROXYSTEROID-4-AZA-COMPOUNDS, COMPOSITIONS AND USES THEREOF | SPHAERA PHARMA PRIVATE LTD (IN) | 2020-08-26 | — | — | EP | disclosed |