Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 16/20 | 0.55 |
| ▸ | TLR7 | Q9NYK1 | 7/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19940905 | 0.88 | TLR8 (0.73) | TLR8TLR7 | |
| SCHEMBL19940723 | 0.88 | TLR8 (0.73) | TLR8TLR7 | |
| SCHEMBL19991818 | 0.88 | TLR8 (0.55) | TLR8TLR7L3MBTL1 | |
| SCHEMBL19940947 | 0.88 | TLR8 (0.55) | TLR8TLR7L3MBTL1 | |
| SCHEMBL18125210 | 0.82 | TLR8 (0.74) | TLR8TLR7 | |
| SCHEMBL18125191 | 0.82 | TLR8 (0.74) | TLR8TLR7 | |
| SCHEMBL18109696 | 0.81 | TLR8 (0.74) | TLR8TLR7 | |
| SCHEMBL18109762 | 0.81 | TLR8 (0.57) | TLR8TLR7L3MBTL1 | |
| SCHEMBL18109697 | 0.81 | TLR8 (0.74) | TLR8TLR7 | |
| SCHEMBL18109764 | 0.81 | TLR8 (0.57) | TLR8TLR7L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3507288-B1 | 4,6-DIAMINO-PYRIDO[3,2-D]PYRIMIDINE DERIVATIES AS TOLL LIKE RECEPTOR MODULATORS | GILEAD SCIENCES INC (US) | 2020-08-26 | — | — | EP | disclosed |