Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 20/20 | 0.48 |
| ▸ | BRD4 | O60885 | 5/20 | 0.48 |
| ▸ | EP300 | Q09472 | 1/20 | 0.48 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.48 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22368649 | 0.86 | CREBBP (0.62) | CREBBPBRD4EP300CECR2BRD9 | |
| SCHEMBL17673177 | 0.78 | CREBBP (0.75) | CREBBPBRD4EP300CECR2BRD9 | |
| SCHEMBL22368686 | 0.76 | CREBBP (0.51) | CREBBPBRD4EP300CECR2BRD9 | |
| SCHEMBL22368719 | 0.73 | CREBBP (0.48) | CREBBPBRD4EP300CECR2BRD9 | |
| SCHEMBL22368761 | 0.71 | AXL (0.55) | CREBBPBRD4EP300CECR2BRD9 | |
| SCHEMBL17673166 | 0.69 | CREBBP (0.47) | CREBBPBRD4EP300CECR2BRD9 | |
| SCHEMBL22369009 | 0.69 | CREBBP (0.56) | CREBBPBRD4EP300CECR2BRD9 | |
| SCHEMBL17680738 | 0.68 | CREBBP (0.51) | CREBBPBRD4EP300CECR2BRD9 | |
| SCHEMBL17673271 | 0.67 | AXL (0.59) | CREBBPBRD4EP300CECR2BRD9 | |
| SCHEMBL23682751 | 0.66 | CREBBP (0.72) | CREBBPBRD4EP300CECR2BRD9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3204360-B1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH INC (US) | 2020-08-26 | — | — | EP | disclosed |