SCHEMBL22368795

SCHEMBL22368795

CSc1cccc(-c2cccc3c2NCCC(=O)N3)c1

nearest known ligand 0.44

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CREBBP Q92793 19/20 0.44
BRD4 O60885 14/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22369217 0.80 CREBBP (0.64) CREBBPBRD4
SCHEMBL22368880 0.80 CREBBP (0.64) CREBBPBRD4
SCHEMBL22368856 0.80 CREBBP (0.62) CREBBPBRD4
SCHEMBL17680875 0.79 CREBBP (0.64) CREBBPBRD4
SCHEMBL17680966 0.77 CREBBP (0.68) CREBBPBRD4
SCHEMBL22369180 0.77 CREBBP (0.66) CREBBPBRD4
SCHEMBL22368642 0.77 CREBBP (0.48) CREBBPBRD4
SCHEMBL17680876 0.77 CREBBP (0.61) CREBBPBRD4
SCHEMBL17680951 0.77 CREBBP (0.43) CREBBPBRD4
SCHEMBL22368937 0.77 CREBBP (0.64) CREBBPBRD4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3204360-B1 THERAPEUTIC COMPOUNDS AND USES THEREOF GENENTECH INC (US) 2020-08-26 EP disclosed