Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 10/20 | 0.67 |
| ▸ | BRD4 | O60885 | 8/20 | 0.43 |
| ▸ | GSK3B | P49841 | 3/20 | 0.41 |
| ▸ | GSK3A | P49840 | 2/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.41 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.40 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17680582 | 0.81 | CREBBP (1.00) | CREBBPBRD4 | |
| SCHEMBL22369150 | 0.77 | CREBBP (0.75) | CREBBPBRD4 | |
| SCHEMBL22369113 | 0.76 | CREBBP (0.56) | CREBBPBRD4ALDH1A1HPGD | |
| SCHEMBL19539048 | 0.76 | CREBBP (0.65) | CREBBPBRD4GSK3BGSK3ACDK5 | |
| SCHEMBL22369229 | 0.74 | CREBBP (0.51) | CREBBPBRD4 | |
| SCHEMBL22369020 | 0.73 | CREBBP (0.69) | CREBBPBRD4 | |
| SCHEMBL17680744 | 0.72 | CREBBP (0.76) | CREBBPBRD4 | |
| SCHEMBL22369022 | 0.72 | CREBBP (0.76) | CREBBPBRD4 | |
| SCHEMBL22369155 | 0.71 | CREBBP (0.70) | CREBBPBRD4 | |
| SCHEMBL15964658 | 0.71 | CREBBP (0.55) | CREBBPBRD4GSK3BCDK5CDK5R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3204360-B1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH INC (US) | 2020-08-26 | — | — | EP | disclosed |