Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | ACP1 | P24666 | 1/20 | 0.40 |
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2180555 | 0.90 | PDE10A (0.44) | ACHEKDM4EGAATP53HTT | |
| SCHEMBL2180559 | 0.90 | PDE10A (0.44) | ACHEKDM4EGAATP53HTT | |
| Hydrochloric Acid SCHEMBL2176900 | 0.89 | PDE10A (0.44) | ACHEKDM4EGAATP53HTT | |
| Hydrochloric Acid SCHEMBL2176907 | 0.89 | PDE10A (0.44) | ACHEKDM4EGAATP53HTT | |
| SCHEMBL2178921 | 0.76 | KDM4E (0.47) | ACHEKDM4EGAATP53HTT | |
| SCHEMBL2178924 | 0.76 | KDM4E (0.47) | ACHEKDM4EGAATP53HTT | |
| SCHEMBL12408672 | 0.75 | PDE10A (0.49) | ACHEKDM4EGAATP53HTT | |
| Hydrochloric Acid SCHEMBL2178151 | 0.74 | PDE10A (0.48) | ACHEKDM4EGAATP53HTT | |
| Hydrochloric Acid SCHEMBL2178155 | 0.74 | PDE10A (0.48) | ACHEKDM4EGAATP53HTT | |
| SCHEMBL2176837 | 0.74 | KDM4E (0.47) | ACHEKDM4EGAATP53HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2342191-A1 | AROMATIC NITROGEN-CONTAINING 6-MEMBERED RING COMPOUNDS AND THEIR USE | Mitsubishi Tanabe Pharma Corporation (JP) | 2011-07-13 | — | — | EP | disclosed |
| WO-2010030027-A1 | AROMATIC NITROGEN-CONTAINING 6-MEMBERED RING COMPOUNDS AND THEIR USE | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2010-03-18 | — | — | WO | disclosed |