Sugi Predict

Sugi Predict / Compounds / SCHEMBL2237246

SCHEMBL2237246

SCHEMBL2237246

CCc1ccccc1OS(=O)(=O)c1ccc(N2CCN(C)C2=O)cc1

nearest known ligand 0.47

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ CYP1A1 P04798 11/20 0.47
▸ DHODH Q02127 1/20 0.46
▸ MEN1 O00255 3/20 0.38
▸ KMT2A Q03164 3/20 0.38
▸ L3MBTL1 Q9Y468 1/20 0.37
▸ ADRB2 P07550 1/20 0.36
▸ ADRB1 P08588 1/20 0.36
▸ ADRB3 P13945 1/20 0.36
▸ KDM4E B2RXH2 1/20 0.36
▸ ALDH1A1 P00352 1/20 0.36
▸ F2 P00734 1/20 0.36
▸ MAPT P10636 1/20 0.36
▸ VDR P11473 1/20 0.36
▸ TP53 P04637 1/20 0.36
▸ ENPP2 Q13822 1/20 0.36
▸ NPC1 O15118 1/20 0.36
▸ RAB9A P51151 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2240159 0.92 CYP1A1 (0.48) CYP1A1DHODHMEN1KMT2AL3MBTL1
SCHEMBL14119647 0.87 CYP1A1 (0.63) CYP1A1DHODHMEN1KMT2A
SCHEMBL2236664 0.85 CYP1A1 (0.44) CYP1A1MEN1KMT2AL3MBTL1ALDH1A1
SCHEMBL2305210 0.82 DHODH (0.47) CYP1A1DHODHMEN1KMT2AL3MBTL1
SCHEMBL12353938 0.81 CYP1A1 (0.61) CYP1A1DHODHENPP2
SCHEMBL2235316 0.79 DHODH (0.45) CYP1A1DHODHMEN1KMT2AL3MBTL1
SCHEMBL2236331 0.77 CYP1A1 (0.48) CYP1A1ADRB2ADRB1ADRB3MAPT
SCHEMBL2237460 0.77 CYP1A1 (0.49) CYP1A1
SCHEMBL2237271 0.76 CYP1A1 (0.45) CYP1A1MEN1KMT2AKDM4E
SCHEMBL14119561 0.76 CYP1A1 (0.72) CYP1A1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9034888-B2 Substituted 2-imidazolidones and analogs UNIVERSITE LAVAL (CA) 2015-05-19 — — US disclosed
US-9034888-B2 Substituted 2-imidazolidones and analogs UNIVERSITE LAVAL (CA) 2015-05-19 — — US disclosed
US-9034888-B2 Substituted 2-imidazolidones and analogs UNIVERSITE LAVAL (CA) 2015-05-19 — — US disclosed
EP-2536693-A1 SUBSTITUTED 2-IMIDAZOLIDONES AND ANALOGS Université Laval (CA) 2012-12-26 — — EP disclosed
US-20120309777-A1 SUBSTITUTED 2-IMIDAZOLIDONES AND ANALOGS UNIVERSITE LAVAL (CA) 2012-12-06 — — US disclosed
US-20120309777-A1 SUBSTITUTED 2-IMIDAZOLIDONES AND ANALOGS UNIVERSITE LAVAL (CA) 2012-12-06 — — US disclosed
US-20120309777-A1 SUBSTITUTED 2-IMIDAZOLIDONES AND ANALOGS UNIVERSITE LAVAL (CA) 2012-12-06 — — US disclosed
WO-2011100840-A1 SUBSTITUTED 2-IMIDAZOLIDONES AND ANALOGS UNIVERSITé LAVAL (CA) 2011-08-25 — — WO disclosed
WO-2011100840-A1 SUBSTITUTED 2-IMIDAZOLIDONES AND ANALOGS UNIVERSITé LAVAL (CA) 2011-08-25 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120309777-A1 SUBSTITUTED 2-IMIDAZOLIDONES AND ANALOGS CCNY, RPS4Y1, TPX2 CYP1A1 1777/4885DHODH 4160/4885MEN1 1673/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.