Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 20/20 | 0.64 |
| ▸ | PDE4A | P27815 | 2/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2238693 | 0.82 | PDE4B (0.50) | PDE4B | |
| SCHEMBL728524 | 0.80 | PDE4B (0.53) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL728545 | 0.80 | PDE4B (0.53) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL2234544 | 0.80 | PDE4B (0.58) | PDE4B | |
| SCHEMBL2235723 | 0.80 | PDE4B (0.56) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL9958385 | 0.79 | PDE4B (0.57) | PDE4B | |
| SCHEMBL2239410 | 0.78 | PDE4B (0.56) | PDE4B | |
| SCHEMBL2303094 | 0.78 | PDE4B (0.56) | PDE4B | |
| SCHEMBL4365705 | 0.78 | PDE4B (1.00) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL4379192 | 0.74 | PDE4B (0.60) | PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2467376-A1 | BICYCLIC HETEROARYL INHIBITORS OF PDE4 | Kalypsys, Inc. (US) | 2012-06-27 | — | — | EP | disclosed |
| WO-2011093924-A1 | BICYCLIC HETEROARYL INHIBITORS OF PDE4 | KALYPSYS, INC (US) | 2011-08-04 | — | — | WO | disclosed |