Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 5/20 | 0.66 |
| ▸ | CDK5R1 | Q15078 | 5/20 | 0.66 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.66 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.66 |
| ▸ | CDK1 | P06493 | 3/20 | 0.66 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.66 |
| ▸ | PRKACA | P17612 | 3/20 | 0.66 |
| ▸ | PRKACG | P22612 | 3/20 | 0.66 |
| ▸ | PRKACB | P22694 | 3/20 | 0.66 |
| ▸ | GSK3B | P49841 | 3/20 | 0.66 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.66 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.66 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.66 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.66 |
| ▸ | CLK1 | P49759 | 2/20 | 0.66 |
| ▸ | CSNK1G2 | P78368 | 2/20 | 0.66 |
| ▸ | CSNK1G1 | Q9HCP0 | 2/20 | 0.66 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.66 |
| ▸ | PIM1 | P11309 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1839008 | 0.86 | CCNT1 (0.67) | CDK5CDK5R1PDPK1GSK3BCCNT1 | |
| SCHEMBL1836259 | 0.84 | CCNT1 (0.76) | CDK5CDK5R1PDPK1CCNT1CCNA2 | |
| SCHEMBL12572789 | 0.81 | CDK2 (0.52) | CDK5CDK5R1PDPK1CCNB2CDK1 | |
| SCHEMBL1841954 | 0.81 | CCNT1 (0.77) | CDK5CDK5R1PDPK1GSK3BCCNT1 | |
| SCHEMBL1843060 | 0.81 | CCNT1 (0.80) | PDPK1CCNT1CCNA2CDK2CDK9 | |
| SCHEMBL1604060 | 0.80 | CDK2 (0.67) | CDK5PDPK1CDK1PRKACAGSK3B | |
| Meridianin C SCHEMBL1612228 | 0.80 | GSK3B (1.00) | CDK5CDK5R1PDPK1CCNB2CDK1 | |
| Meridianin C SCHEMBL30369326 | 0.80 | GSK3B (1.00) | CDK5CDK5R1PDPK1CCNB2CDK1 | |
| SCHEMBL2239305 | 0.79 | CLK1 (0.66) | CDK5CDK5R1PDPK1GSK3BCLK1 | |
| SCHEMBL18941992 | 0.79 | CCNT1 (1.00) | GSK3BCCNT1CCNA2CDK2CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113816957-B | 4- (7-azaindole) -2-aminopyrimidine compounds and application thereof | 浙江工业大学 | 2023-04-07 | — | — | CN | disclosed |
| CN-113816957-A | 4- (7-azaindole) -2-aminopyrimidine compounds and application thereof | 浙江工业大学 | 2021-12-21 | — | — | CN | disclosed |
| US-20110201599-A1 | CDK Modulators | EXELIXIS, INC. (US) | 2011-08-18 | — | — | US | disclosed |
| US-20110201599-A1 | CDK Modulators | EXELIXIS, INC. (US) | 2011-08-18 | — | — | US | disclosed |
| US-20110201599-A1 | CDK Modulators | EXELIXIS, INC. (US) | 2011-08-18 | — | — | US | disclosed |
| CN-102143746-A | CDK modulators | EXELIXIS INC | 2011-08-03 | — | — | CN | disclosed |
| WO-2010003133-A2 | CDK MODULATORS | EXELIXIS INC. (US) | 2010-01-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110201599-A1 | CDK Modulators | CDK3, CDK1, CDKL1 | CDK5 24/4885CDK5R1 41/4885PDPK1 382/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.