Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 7/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 11/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 2/20 | 0.43 |
| ▸ | BCR | P11274 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2239410 | 0.84 | PDE4B (0.56) | SRCPDE4BCYP2D6TSHRFYN | |
| SCHEMBL9958385 | 0.83 | PDE4B (0.57) | SRCPDE4BCYP2D6TSHRFYN | |
| SCHEMBL2234544 | 0.81 | PDE4B (0.58) | SRCPDE4BCYP2D6TSHRFYN | |
| SCHEMBL3683693 | 0.80 | PDE4B (0.71) | SRCPDE4B | |
| SCHEMBL730436 | 0.79 | PDE4B (0.51) | SRCPDE4BCYP2D6TSHRFYN | |
| SCHEMBL730970 | 0.79 | PDE4B (0.51) | SRCPDE4BCYP2D6TSHRFYN | |
| SCHEMBL3678989 | 0.79 | PDE4B (0.71) | SRCPDE4BCYP2D6TSHR | |
| SCHEMBL729253 | 0.78 | PDE4B (0.51) | SRCPDE4BCYP2D6TSHRFYN | |
| SCHEMBL730552 | 0.76 | PDE4B (0.50) | SRCPDE4BCYP2D6TSHRFYN | |
| SCHEMBL2234434 | 0.75 | TSHR (0.46) | SRCPDE4BCYP2D6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2467376-A1 | BICYCLIC HETEROARYL INHIBITORS OF PDE4 | Kalypsys, Inc. (US) | 2012-06-27 | — | — | EP | disclosed |
| WO-2011093924-A1 | BICYCLIC HETEROARYL INHIBITORS OF PDE4 | KALYPSYS, INC (US) | 2011-08-04 | — | — | WO | disclosed |