Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 9/20 | 0.64 |
| ▸ | F2 | P00734 | 8/20 | 0.64 |
| ▸ | PLAT | P00750 | 8/20 | 0.64 |
| ▸ | PLG | P00747 | 8/20 | 0.64 |
| ▸ | F10 | P00742 | 3/20 | 0.54 |
| ▸ | KLK8 | O60259 | 1/20 | 0.52 |
| ▸ | KLK2 | P20151 | 1/20 | 0.52 |
| ▸ | KLK4 | Q9Y5K2 | 1/20 | 0.52 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | PPARA | Q07869 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | ELANE | P08246 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13739678 | 0.92 | PLAU (0.53) | PLAUF2PLATPLGF10 | |
| SCHEMBL2247009 | 0.91 | F2 (0.68) | PLAUF2PLATPLGF10 | |
| SCHEMBL2244734 | 0.91 | PLAU (0.62) | PLAUF2PLATPLGF10 | |
| SCHEMBL2242628 | 0.89 | PLAU (0.58) | PLAUF2PLATPLGF10 | |
| SCHEMBL2242586 | 0.86 | F2 (0.73) | PLAUF2PLATPLGF10 | |
| SCHEMBL2245991 | 0.85 | PLAU (0.71) | PLAUF2PLATPLGF10 | |
| SCHEMBL13740229 | 0.84 | PLAU (0.59) | PLAUF2PLATPLGF10 | |
| SCHEMBL2243199 | 0.82 | PLAU (0.80) | PLAUF2PLATPLGF10 | |
| SCHEMBL2242137 | 0.82 | PLAU (0.69) | PLAUF2PLATPLGF10 | |
| SCHEMBL13739787 | 0.82 | PLAU (0.49) | PLAUF2PLATPLGF10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940856-B1 | NOVEL UROKINASE INHIBITORS | UNIV ANTWERPEN (BE) | 2014-10-08 | — | — | EP | disclosed |
| US-8003627-B2 | Urokinase inhibitors | UNIVERSITEIT ANTWERPEN (BE) | 2011-08-23 | — | — | US | disclosed |
| US-20080312191-A1 | Novel Urokinase Inhibitors | UNIVERSITEIT ANTWERPEN (BE) | 2008-12-18 | — | — | US | disclosed |
| EP-1940856-A1 | NOVEL UROKINASE INHIBITORS | Universiteit Antwerpen (BE) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007045496-A1 | NOVEL UROKINASE INHIBITORS | UNIVERSITEIT ANTWERPEN (BE) | 2007-04-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312191-A1 | Novel Urokinase Inhibitors | PLAU, PLAUR, SERPINE1 | PLAU 1/4885F2 241/4885PLAT 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.