Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK9 | P50750 | 9/20 | 0.54 |
| ▸ | CCNT1 | O60563 | 8/20 | 0.54 |
| ▸ | CCNA2 | P20248 | 8/20 | 0.54 |
| ▸ | CDK2 | P24941 | 8/20 | 0.54 |
| ▸ | CDK5 | Q00535 | 7/20 | 0.54 |
| ▸ | CDK5R1 | Q15078 | 7/20 | 0.54 |
| ▸ | CCNA1 | P78396 | 6/20 | 0.54 |
| ▸ | GSK3B | P49841 | 3/20 | 0.48 |
| ▸ | JAK2 | O60674 | 3/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.46 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | HTR5A | P47898 | 1/20 | 0.43 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.43 |
| ▸ | CDC7 | O00311 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1840135 | 0.75 | DYRK1A (0.52) | CDK9CCNT1CCNA2CDK2CDK5 | |
| SCHEMBL1838343 | 0.75 | GSK3B (0.53) | CDK9CCNT1CCNA2CDK2CDK5 | |
| SCHEMBL1840513 | 0.74 | GSK3B (0.46) | CDK9CCNT1CCNA2CDK2CDK5 | |
| SCHEMBL3201184 | 0.71 | IKBKB (0.43) | CDK9CCNT1CDK5CDK5R1GSK3B | |
| SCHEMBL31660993 | 0.71 | IKBKB (0.43) | CDK9CCNT1CDK5CDK5R1GSK3B | |
| SCHEMBL13977463 | 0.70 | JAK2 (0.53) | CDK9CCNT1CCNA2CDK2CDK5 | |
| Meriolin 3 SCHEMBL2996575 | 0.70 | CCNT1 (1.00) | CDK9CCNT1CCNA2CDK2CDK5 | |
| Meriolin 3 SCHEMBL29489951 | 0.70 | CCNT1 (1.00) | CDK9CCNT1CCNA2CDK2CDK5 | |
| SCHEMBL2087226 | 0.69 | CCNB2 (0.42) | CDK9CCNT1CDK5CDK5R1GSK3B | |
| SCHEMBL2087223 | 0.69 | CCNT1 (0.53) | CDK9CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110201599-A1 | CDK Modulators | EXELIXIS, INC. (US) | 2011-08-18 | — | — | US | disclosed |
| US-20110201599-A1 | CDK Modulators | EXELIXIS, INC. (US) | 2011-08-18 | — | — | US | disclosed |
| US-20110201599-A1 | CDK Modulators | EXELIXIS, INC. (US) | 2011-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110201599-A1 | CDK Modulators | CDK3, CDK1, CDKL1 | CDK9 6/4885CCNT1 25/4885CCNA2 39/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.