Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 11/20 | 0.56 |
| ▸ | DYRK2 | Q92630 | 11/20 | 0.56 |
| ▸ | DYRK1B | Q9Y463 | 10/20 | 0.51 |
| ▸ | DYRK3 | O43781 | 9/20 | 0.51 |
| ▸ | CDK5 | Q00535 | 6/20 | 0.51 |
| ▸ | CDK5R1 | Q15078 | 6/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 6/20 | 0.51 |
| ▸ | CDK2 | P24941 | 6/20 | 0.51 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.51 |
| ▸ | CDK9 | P50750 | 4/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.49 |
| ▸ | ATR | Q13535 | 1/20 | 0.49 |
| ▸ | FYN | P06241 | 5/20 | 0.48 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.48 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2236203 | 0.83 | DYRK1A (0.62) | DYRK1ADYRK2DYRK1BDYRK3CDK5 | |
| SCHEMBL3514282 | 0.82 | FYN (0.66) | DYRK1ADYRK2DYRK1BDYRK3CDK5 | |
| SCHEMBL3043884 | 0.81 | FYN (0.67) | DYRK1ADYRK2DYRK1BDYRK3CDK5 | |
| SCHEMBL21643914 | 0.80 | FYN (0.63) | PIK3CAATRFYN | |
| SCHEMBL16947087 | 0.79 | TNF (0.47) | DYRK1ADYRK2DYRK1BDYRK3CDK5 | |
| SCHEMBL16331402 | 0.79 | FYN (0.64) | DYRK1ADYRK2DYRK1BDYRK3CDK5 | |
| SCHEMBL15288602 | 0.78 | DYRK1A (0.70) | DYRK1ADYRK2DYRK1BDYRK3CDK5 | |
| SCHEMBL30442968 | 0.77 | DYRK1A (0.50) | DYRK1ADYRK2DYRK1BDYRK3CDK5 | |
| SCHEMBL30444086 | 0.77 | MKNK1 (0.48) | DYRK1ADYRK2DYRK1BDYRK3CDK5 | |
| SCHEMBL2948779 | 0.77 | DYRK1A (0.68) | DYRK1ADYRK2DYRK1BDYRK3CDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011101640-A1 | FUSED HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF MALARIA | MEDICAL RESEARCH COUNCIL TECHNOLOGY (GB) | 2011-08-25 | — | — | WO | disclosed |
| WO-2011101640-A1 | FUSED HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF MALARIA | MEDICAL RESEARCH COUNCIL TECHNOLOGY (GB) | 2011-08-25 | — | — | WO | disclosed |