Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 12/20 | 0.52 |
| ▸ | ACE | P12821 | 5/20 | 0.52 |
| ▸ | MMEL1 | Q495T6 | 4/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21241434 | 1.00 | MME (0.52) | MMEACEMMEL1 | |
| SCHEMBL21221273 | 0.91 | MME (0.58) | MMEACEMMEL1 | |
| SCHEMBL21221272 | 0.91 | MME (0.58) | MMEACEMMEL1 | |
| SCHEMBL21241267 | 0.90 | MME (0.49) | MMEACEMMEL1 | |
| SCHEMBL17164911 | 0.85 | MME (0.60) | MMEACEMMEL1 | |
| SCHEMBL18575929 | 0.85 | MME (0.60) | MMEACEMMEL1 | |
| SCHEMBL22585410 | 0.81 | MME (0.74) | MMEACEMMEL1 | |
| Sacubitril SCHEMBL22420467 | 0.81 | MME (0.77) | MMEACEMMEL1 | |
| Sacubitril SCHEMBL8214132 | 0.81 | MME (0.77) | MMEACEMMEL1 | |
| Sacubitril SCHEMBL18059568 | 0.81 | MME (0.77) | MMEACEMMEL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111655671-A | Substituted bisphenyl butyrate derivatives as NEP inhibitors | 诺华股份有限公司 | 2020-09-11 | — | — | CN | claimed |
| EP-3544966-B1 | SUBSTITUTED BISPHENYL BUTANOIC ESTER DERIVATIVES AS NEP INHIBITORS | NOVARTIS AG (CH) | 2020-09-09 | — | — | EP | claimed |
| CN-111655671-A | Substituted bisphenyl butyrate derivatives as NEP inhibitors | 诺华股份有限公司 | 2020-09-11 | — | — | CN | disclosed |