Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 4/20 | 0.43 |
| ▸ | PNP | P00491 | 4/20 | 0.41 |
| ▸ | PI4KA | P42356 | 2/20 | 0.37 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.37 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.37 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | XDH | P47989 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.36 |
| ▸ | BCL2 | P10415 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14190552 | 0.78 | PDPK1 (0.76) | PDPK1ALDH1A1PARP1PNPACHE | |
| SCHEMBL29159098 | 0.77 | PDPK1 (0.49) | PDPK1ALDH1A1PARP1PNPLRRK2 | |
| SCHEMBL20187560 | 0.77 | PDPK1 (0.49) | PDPK1ALDH1A1PARP1PNPLRRK2 | |
| SCHEMBL38653002 | 0.75 | PDPK1 (0.44) | PDPK1ALDH1A1PARP1PNPGDA | |
| SCHEMBL23477080 | 0.73 | HPGD (0.50) | PDPK1ALDH1A1PARP1PNP | |
| SCHEMBL18521204 | 0.73 | PDPK1 (0.49) | PDPK1ALDH1A1PNP | |
| SCHEMBL18521268 | 0.73 | PDPK1 (0.53) | PDPK1ALDH1A1PARP1PNPLMNA | |
| SCHEMBL4736800 | 0.72 | PNP (0.50) | PDPK1ALDH1A1PARP1PNP | |
| SCHEMBL17966187 | 0.70 | KDM4E (0.53) | PDPK1ALDH1A1PNPLMNAPIM1 | |
| SCHEMBL670236 | 0.70 | PDPK1 (0.46) | PDPK1ALDH1A1PARP1PNP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10766919-B2 | Cyclic di-nucleotide compounds as sting agonists | MERCK SHARP & DOHME CORP. (US) | 2020-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10766919-B2 | Cyclic di-nucleotide compounds as sting agonists | STING1, CGAS, IFNAR1 | PDPK1 1687/4885ALDH1A1 4183/4885PARP1 147/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.