SCHEMBL22400958

SCHEMBL22400958

C=CC(=O)N1CC(Nc2cncc(-c3cnc(Oc4cccc(OC(F)(F)F)c4)nc3)n2)C1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
EGFR P00533 20/20 1.00
BTK Q06187 18/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30091751 1.00 EGFR (1.00) EGFRBTK
SCHEMBL22400876 0.91 EGFR (1.00) EGFRBTK
SCHEMBL22400936 0.90 EGFR (1.00) EGFRBTK
SCHEMBL30091775 0.90 EGFR (1.00) EGFRBTK
SCHEMBL22404948 0.90 EGFR (1.00) EGFRBTK
SCHEMBL30091776 0.90 EGFR (1.00) EGFRBTK
SCHEMBL30091774 0.90 EGFR (1.00) EGFRBTK
SCHEMBL22404967 0.90 EGFR (1.00) EGFRBTK
SCHEMBL22400890 0.88 EGFR (1.00) EGFRBTK
SCHEMBL22404951 0.87 EGFR (1.00) EGFRBTK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111278818-B BTK inhibitor compounds 伊莱利利公司 2023-03-28 CN claimed
US-11542249-B2 BTK inhibitor compounds ELI LILLY AND COMPANY (US) 2023-01-03 US claimed
EP-3707133-B1 BTK INHIBITOR COMPOUNDS LILLY CO ELI (US) 2021-12-15 EP claimed
US-20200290997-A1 BTK INHIBITOR COMPOUNDS ELI LILLY AND COMPANY 2020-09-17 US claimed
EP-3707133-A1 BTK INHIBITOR COMPOUNDS Eli Lilly and Company (US) 2020-09-16 EP claimed
CN-111278818-A BTK inhibitor compounds 伊莱利利公司 2020-06-12 CN claimed
CN-111278818-B BTK inhibitor compounds 伊莱利利公司 2023-03-28 CN disclosed
US-11542249-B2 BTK inhibitor compounds ELI LILLY AND COMPANY (US) 2023-01-03 US disclosed
US-11542249-B2 BTK inhibitor compounds ELI LILLY AND COMPANY (US) 2023-01-03 US disclosed
EP-3707133-B1 BTK INHIBITOR COMPOUNDS LILLY CO ELI (US) 2021-12-15 EP disclosed
US-20200290997-A1 BTK INHIBITOR COMPOUNDS ELI LILLY AND COMPANY 2020-09-17 US disclosed
US-20200290997-A1 BTK INHIBITOR COMPOUNDS ELI LILLY AND COMPANY 2020-09-17 US disclosed
CN-111278818-A BTK inhibitor compounds 伊莱利利公司 2020-06-12 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200290997-A1 BTK INHIBITOR COMPOUNDS BTK, SYK, LCK EGFR 403/4885BTK 1/4885
US-11542249-B2 BTK inhibitor compounds BTK, SYK, LCK EGFR 380/4885BTK 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.