Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 16/20 | 0.63 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL728529 | 0.94 | PDE4B (0.70) | PDE4BPDE4DPDE4APDE4CCNR1 | |
| SCHEMBL730473 | 0.93 | PDE4B (0.60) | PDE4BPDE4DPDE4APDE4CCNR1 | |
| SCHEMBL729330 | 0.93 | PDE4B (0.57) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL731157 | 0.92 | PDE4B (0.70) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL730867 | 0.91 | PDE4B (0.71) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL730980 | 0.91 | PDE4B (0.71) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL730855 | 0.91 | PDE4B (0.71) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL2238270 | 0.91 | PDE4B (0.60) | PDE4BPDE4DPDE4APDE4CCNR1 | |
| SCHEMBL730562 | 0.91 | PDE4B (0.71) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL729417 | 0.90 | PDE4B (0.61) | PDE4BPDE4DPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2467376-A1 | BICYCLIC HETEROARYL INHIBITORS OF PDE4 | Kalypsys, Inc. (US) | 2012-06-27 | — | — | EP | disclosed |
| WO-2011093924-A1 | BICYCLIC HETEROARYL INHIBITORS OF PDE4 | KALYPSYS, INC (US) | 2011-08-04 | — | — | WO | disclosed |