Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20437123 | 0.86 | NPC1 (0.37) | NPC1MAPTDGAT1 | |
| SCHEMBL30443412 | 0.85 | NPC1 (0.39) | NPC1MAPT | |
| SCHEMBL30442857 | 0.85 | NPC1 (0.36) | NPC1MAPTDGAT1 | |
| SCHEMBL1963517 | 0.85 | NPC1 (0.36) | NPC1MAPT | |
| SCHEMBL20839775 | 0.83 | NPC1 (0.38) | NPC1MAPTDGAT1 | |
| SCHEMBL20839822 | 0.83 | NPC1 (0.35) | NPC1MAPTDGAT1 | |
| SCHEMBL34475404 | 0.81 | NPC1 (0.33) | NPC1MAPTDGAT1 | |
| SCHEMBL31662605 | 0.79 | NPC1 (0.47) | NPC1MAPTDGAT1 | |
| SCHEMBL23326952 | 0.78 | NPC1 (0.38) | NPC1MAPT | |
| SCHEMBL21930734 | 0.78 | AURKA (0.39) | NPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110201599-A1 | CDK Modulators | EXELIXIS, INC. (US) | 2011-08-18 | — | — | US | disclosed |
| US-20110201599-A1 | CDK Modulators | EXELIXIS, INC. (US) | 2011-08-18 | — | — | US | disclosed |
| US-20110201599-A1 | CDK Modulators | EXELIXIS, INC. (US) | 2011-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110201599-A1 | CDK Modulators | CDK3, CDK1, CDKL1 | NPC1 4499/4885MAPT 2120/4885DGAT1 3881/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.