Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 7/20 | 0.54 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 4/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.46 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.46 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.45 |
| ▸ | CDK7 | P50613 | 3/20 | 0.44 |
| ▸ | CDK9 | P50750 | 3/20 | 0.44 |
| ▸ | CDK1 | P06493 | 2/20 | 0.44 |
| ▸ | CDK4 | P11802 | 2/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.44 |
| ▸ | CCNH | P51946 | 2/20 | 0.44 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.44 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.44 |
| ▸ | CDK8 | P49336 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 5/20 | 0.43 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.42 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL22413123 | 0.99 | CCNT1 (0.53) | CCNT1GSK3BCDK2CHEK1CCNA2 | |
| SCHEMBL22434484 | 0.90 | GSK3B (0.48) | CCNT1GSK3BCDK2CHEK1CCNA2 | |
| Hydrochloric Acid SCHEMBL22413120 | 0.89 | GSK3B (0.47) | CCNT1GSK3BCDK2CHEK1CCNA2 | |
| Hydrochloric Acid SCHEMBL29582787 | 0.89 | GSK3B (0.47) | CCNT1GSK3BCDK2CHEK1CCNA2 | |
| SCHEMBL29583558 | 0.87 | CCNT1 (0.52) | CCNT1GSK3BCDK2CHEK1CCNA2 | |
| SCHEMBL22413324 | 0.87 | CCNT1 (0.52) | CCNT1GSK3BCDK2CHEK1CCNA2 | |
| SCHEMBL22413326 | 0.87 | CCNT1 (0.52) | CCNT1GSK3BCDK2CHEK1CCNA2 | |
| SCHEMBL22434416 | 0.85 | CDK2 (0.53) | CCNT1GSK3BCDK2CHEK1MAPKAPK2 | |
| Hydrochloric Acid SCHEMBL22413149 | 0.84 | CDK2 (0.52) | CCNT1GSK3BCDK2CHEK1MAPKAPK2 | |
| Hydrochloric Acid SCHEMBL29582696 | 0.84 | CDK2 (0.52) | CCNT1GSK3BCDK2CHEK1MAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220144841-A1 | TRISUBSTITUTED PYRAZOLO [1,5-A] PYRIMIDINE COMPOUNDS AS CDK7 INHIBITORS | THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE | 2022-05-12 | — | — | US | disclosed |
| US-20220144841-A1 | TRISUBSTITUTED PYRAZOLO [1,5-A] PYRIMIDINE COMPOUNDS AS CDK7 INHIBITORS | THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE | 2022-05-12 | — | — | US | disclosed |
| WO-2020186196-A1 | TRISUBSTITUTED PYRAZOLO [1,5-A] PYRIMIDINE COMPOUNDS AS CDK7 INHIBITORS | THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2020-09-17 | — | — | WO | disclosed |
| WO-2020186196-A1 | TRISUBSTITUTED PYRAZOLO [1,5-A] PYRIMIDINE COMPOUNDS AS CDK7 INHIBITORS | THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2020-09-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220144841-A1 | TRISUBSTITUTED PYRAZOLO [1,5-A] PYRIMIDINE COMPOUNDS AS CDK7 INHIBITORS | CDK7, CDK8, CDK3 | CCNT1 39/4885GSK3B 383/4885CDK2 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.