Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK3 | Q13188 | 13/20 | 1.00 |
| ▸ | STK4 | Q13043 | 10/20 | 1.00 |
| ▸ | EGFR | P00533 | 5/20 | 0.83 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.83 |
| ▸ | STK25 | O00506 | 1/20 | 0.72 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.72 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.72 |
| ▸ | GAK | O14976 | 1/20 | 0.72 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.72 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.72 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.72 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.72 |
| ▸ | STK17B | O94768 | 1/20 | 0.72 |
| ▸ | STK10 | O94804 | 1/20 | 0.72 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.72 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.72 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.72 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.72 |
| ▸ | ABL1 | P00519 | 1/20 | 0.72 |
| ▸ | INSR | P06213 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22419640 | 0.94 | STK4 (0.90) | STK3STK4EGFRERBB2STK25 | |
| SCHEMBL3476976 | 0.93 | STK4 (0.88) | STK3STK4EGFRERBB2STK25 | |
| SCHEMBL22419655 | 0.92 | STK4 (1.00) | STK3STK4EGFRERBB2 | |
| SCHEMBL31661503 | 0.92 | STK4 (1.00) | STK3STK4EGFRERBB2 | |
| SCHEMBL22419641 | 0.92 | STK3 (0.85) | STK3STK4EGFRERBB2STK25 | |
| SCHEMBL22419770 | 0.92 | STK4 (1.00) | STK3STK4EGFRERBB2STK25 | |
| SCHEMBL3471317 | 0.91 | EGFR (1.00) | STK3STK4EGFRERBB2STK25 | |
| SCHEMBL18343664 | 0.90 | STK3 (1.00) | STK3STK4EGFRERBB2STK25 | |
| SCHEMBL22419677 | 0.90 | STK3 (1.00) | STK3STK4EGFRERBB2STK25 | |
| SCHEMBL22419646 | 0.90 | STK3 (0.92) | STK3STK4EGFRERBB2STK25 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11427560-B2 | Composition and methods for inhibiting mammalian sterile 20-like kinase 1 | THE SCRIPPS RESEARCH INSTITUTE (US) | 2022-08-30 | — | — | US | disclosed |
| US-20210061784-A1 | COMPOSITION AND METHODS FOR INHIBITING MAMMALIAN STERILE 20-LIKE KINASE 1 | UNIVERSITÄT BREMEN (DE) | 2021-03-04 | — | — | US | disclosed |
| US-10774068-B2 | Composition and methods for inhibiting mammalian sterile 20-like kinase 1 | THE SCRIPPS RESEARCH INSTITUTE (US) | 2020-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210061784-A1 | COMPOSITION AND METHODS FOR INHIBITING MAMMALIAN STERILE 20-LIKE KINASE 1 | TESK2, TESK1, PRKACB | STK3 456/4885STK4 852/4885EGFR 3953/4885 |
| US-11427560-B2 | Composition and methods for inhibiting mammalian sterile 20-like kinase 1 | TESK2, TESK1, PRKACB | STK3 456/4885STK4 852/4885EGFR 3953/4885 |
| US-10774068-B2 | Composition and methods for inhibiting mammalian sterile 20-like kinase 1 | TESK2, TESK1, PRKACB | STK3 456/4885STK4 852/4885EGFR 3953/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.