Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.88 |
| ▸ | BLM | P54132 | 4/20 | 0.88 |
| ▸ | MAPT | P10636 | 5/20 | 0.80 |
| ▸ | THRB | P10828 | 1/20 | 0.80 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | RXRA | P19793 | 1/20 | 0.59 |
| ▸ | RXRB | P28702 | 1/20 | 0.59 |
| ▸ | RXRG | P48443 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.52 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.52 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12184267 | 0.93 | POLB (0.76) | POLBBLMMAPTTHRBP2RY6 | |
| SCHEMBL17748317 | 0.93 | POLB (0.76) | POLBBLMMAPTTHRBP2RY6 | |
| SCHEMBL14669489 | 0.93 | POLB (0.76) | POLBBLMMAPTTHRBP2RY6 | |
| SCHEMBL23519982 | 0.89 | POLB (0.79) | POLBBLMMAPTTHRBP2RY6 | |
| SCHEMBL23499892 | 0.89 | POLB (0.78) | POLBBLMMAPTTHRBP2RY6 | |
| SCHEMBL29878640 | 0.89 | POLB (0.78) | POLBBLMMAPTTHRBP2RY6 | |
| SCHEMBL23499859 | 0.88 | POLB (0.76) | POLBBLMMAPTTHRBP2RY6 | |
| SCHEMBL22420594 | 0.88 | POLB (0.76) | POLBBLMMAPTTHRBP2RY6 | |
| SCHEMBL17752106 | 0.88 | POLB (0.76) | POLBBLMMAPTTHRBP2RY6 | |
| SCHEMBL17752105 | 0.88 | POLB (0.74) | POLBBLMMAPTTHRBP2RY6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10774063-B2 | Materials and method for inhibiting replication protein A and uses thereof | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) | 2020-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10774063-B2 | Materials and method for inhibiting replication protein A and uses thereof | RPA1, RPA3, PCNA | POLB 97/4885BLM 31/4885MAPT 4169/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.