Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 3/20 | 0.45 |
| ▸ | CCND1 | P24385 | 3/20 | 0.45 |
| ▸ | PDE2A | O00408 | 14/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18283132 | 0.87 | PDE2A (0.51) | CDK4CCND1PDE2A | |
| SCHEMBL20156698 | 0.86 | CDK4 (0.43) | CDK4CCND1PDE2AKMT2AMEN1 | |
| SCHEMBL22423089 | 0.84 | CDK4 (0.44) | CDK4CCND1PDE2AKMT2AHTR2C | |
| SCHEMBL22423012 | 0.83 | PDE2A (0.49) | CDK4CCND1PDE2A | |
| SCHEMBL20185144 | 0.82 | PDE2A (0.44) | PDE2A | |
| SCHEMBL18294978 | 0.77 | CDK4 (0.44) | CDK4CCND1PDE2AKMT2AMEN1 | |
| SCHEMBL22422954 | 0.76 | CDK4 (0.50) | CDK4CCND1PDE2AKMT2A | |
| SCHEMBL18282842 | 0.76 | PDE2A (0.46) | CDK4CCND1PDE2A | |
| SCHEMBL18282909 | 0.76 | PDE2A (0.61) | PDE2A | |
| SCHEMBL18282912 | 0.76 | PDE2A (0.61) | PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3302484-B1 | 6-ALKYL DIHYDROPYRAZOLOPYRIMIDINONE COMPOUNDS AS PDE2 INHIBITORS | MERCK SHARP & DOHME (US) | 2020-09-16 | — | — | EP | disclosed |