Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 18/20 | 0.48 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.39 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.39 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.39 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CCND1 | P24385 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18282780 | 0.88 | PDE2A (0.52) | PDE2A | |
| SCHEMBL18282777 | 0.88 | PDE2A (0.52) | PDE2A | |
| SCHEMBL18282897 | 0.88 | PDE2A (0.52) | PDE2A | |
| SCHEMBL18283205 | 0.76 | PDE2A (0.77) | PDE2A | |
| SCHEMBL18282864 | 0.76 | PDE2A (0.77) | PDE2A | |
| SCHEMBL18282863 | 0.76 | PDE2A (0.77) | PDE2A | |
| SCHEMBL22422969 | 0.75 | PDE2A (0.57) | PDE2A | |
| SCHEMBL31548661 | 0.70 | PDE2A (0.63) | PDE2A | |
| SCHEMBL20339535 | 0.70 | PDE2A (0.63) | PDE2A | |
| SCHEMBL20150715 | 0.69 | PDE2A (0.48) | PDE2ACDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3302484-B1 | 6-ALKYL DIHYDROPYRAZOLOPYRIMIDINONE COMPOUNDS AS PDE2 INHIBITORS | MERCK SHARP & DOHME (US) | 2020-09-16 | — | — | EP | disclosed |