Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 20/20 | 0.64 |
| ▸ | PDE9A | O76083 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20156701 | 1.00 | PDE2A (0.64) | PDE2APDE9A | |
| SCHEMBL18282942 | 0.91 | PDE2A (0.76) | PDE2APDE9A | |
| SCHEMBL20150789 | 0.89 | PDE2A (0.66) | PDE2APDE9A | |
| SCHEMBL20150774 | 0.89 | PDE2A (0.66) | PDE2APDE9A | |
| SCHEMBL20150788 | 0.89 | PDE2A (0.66) | PDE2APDE9A | |
| SCHEMBL18282691 | 0.89 | PDE2A (0.58) | PDE2APDE9A | |
| SCHEMBL18283311 | 0.88 | PDE2A (0.80) | PDE2A | |
| SCHEMBL18282985 | 0.88 | PDE2A (0.67) | PDE2APDE9A | |
| SCHEMBL18282946 | 0.88 | PDE2A (0.80) | PDE2A | |
| SCHEMBL18282724 | 0.88 | PDE2A (0.64) | PDE2APDE9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3302484-B1 | 6-ALKYL DIHYDROPYRAZOLOPYRIMIDINONE COMPOUNDS AS PDE2 INHIBITORS | MERCK SHARP & DOHME (US) | 2020-09-16 | — | — | EP | disclosed |