Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRLHR | P49683 | 7/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | RPA1 | P27694 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22410896 | 0.92 | PRLHR (0.49) | PRLHRHDAC6MAPTLMNAKMT2A | |
| SCHEMBL22424700 | 0.91 | PRLHR (0.48) | PRLHRHDAC6MAPTLMNAKMT2A | |
| SCHEMBL22424701 | 0.90 | PRLHR (0.47) | PRLHRHDAC6MAPTLMNAKMT2A | |
| SCHEMBL22410768 | 0.90 | PRLHR (0.47) | PRLHRHDAC6MAPTLMNAKMT2A | |
| SCHEMBL22424690 | 0.90 | PRLHR (0.49) | PRLHRHDAC6MAPTLMNAKMT2A | |
| SCHEMBL22424283 | 0.87 | PRLHR (0.50) | PRLHRHDAC6MAPTLMNAKMT2A | |
| SCHEMBL22424572 | 0.87 | PRLHR (0.47) | PRLHRMAPTLMNAKMT2AMEN1 | |
| SCHEMBL22424388 | 0.87 | PRLHR (0.47) | PRLHRHDAC6MAPTLMNAKMT2A | |
| SCHEMBL22424229 | 0.86 | PRLHR (0.52) | PRLHRHDAC6GRM5HTR1A | |
| SCHEMBL22424695 | 0.86 | PRLHR (0.53) | PRLHRHDAC6MAPTLMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020182990-A1 | FUSED RING PYRIMIDONE DERIVATIVES FOR USE IN THE TREATMENT OF HBV INFECTION OR OF HBV-INDUCED DISEASES | Janssen Sciences Ireland Unlimited Company (IE) | 2020-09-17 | — | — | WO | disclosed |