Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 11/20 | 0.39 |
| ▸ | IDH2 | P48735 | 5/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | MBOAT4 | Q96T53 | 3/20 | 0.34 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29526189 | 0.82 | ACP1 (0.38) | CYP1A2CYP2D6 | |
| SCHEMBL20337764 | 0.82 | ACP1 (0.38) | CYP1A2CYP2D6 | |
| SCHEMBL12936052 | 0.79 | KDM4E (0.43) | — | |
| SCHEMBL14768725 | 0.78 | KMT2A (0.45) | — | |
| SCHEMBL30873825 | 0.76 | MAPT (0.48) | IDH1IDH2CHRM4GRM4JAK2 | |
| SCHEMBL22411290 | 0.76 | MAPT (0.48) | IDH1IDH2CHRM4GRM4JAK2 | |
| SCHEMBL12069134 | 0.75 | MAPK1 (0.44) | JAK2IRAK4 | |
| SCHEMBL26350425 | 0.75 | HRH3 (0.47) | CYP1A2CYP2D6 | |
| SCHEMBL30971323 | 0.75 | CHRM4 (0.36) | IDH1IDH2CHRM4CYP1A2CYP2D6 | |
| SCHEMBL22428682 | 0.71 | GRM4 (0.38) | IDH1CHRM4CYP1A2CYP2D6GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020185738-A1 | HETEROAROMATIC AND HETEROBICYCLIC AROMATIC DERIVATIVES FOR THE TREATMENT OF FERROPTOSIS-RELATED DISORDERS | COLLABORATIVE MEDICINAL DEVELOPMENT, LLC (US) | 2020-09-17 | — | — | WO | disclosed |