Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 19/20 | 0.68 |
| ▸ | LCK | P06239 | 8/20 | 0.68 |
| ▸ | EGFR | P00533 | 6/20 | 0.68 |
| ▸ | ITK | Q08881 | 6/20 | 0.68 |
| ▸ | JAK3 | P52333 | 2/20 | 0.68 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.56 |
| ▸ | NUDT5 | Q9UKK9 | 1/20 | 0.56 |
| ▸ | FYN | P06241 | 4/20 | 0.51 |
| ▸ | LYN | P07948 | 4/20 | 0.51 |
| ▸ | SRC | P12931 | 4/20 | 0.51 |
| ▸ | FLT3 | P36888 | 4/20 | 0.51 |
| ▸ | PTK6 | Q13882 | 4/20 | 0.51 |
| ▸ | HCK | P08631 | 3/20 | 0.51 |
| ▸ | FGR | P09769 | 3/20 | 0.51 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.51 |
| ▸ | BRAF | P15056 | 3/20 | 0.51 |
| ▸ | YES1 | P07947 | 2/20 | 0.51 |
| ▸ | BLK | P51451 | 2/20 | 0.51 |
| ▸ | BMX | P51813 | 2/20 | 0.51 |
| ▸ | MAP2K5 | Q13163 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14617765 | 0.87 | BTK (0.76) | BTKLCKEGFRITKJAK3 | |
| SCHEMBL14617791 | 0.85 | BTK (0.78) | BTKLCKEGFRITKJAK3 | |
| SCHEMBL15517319 | 0.85 | BTK (0.81) | BTKLCKEGFRITKJAK3 | |
| SCHEMBL17090646 | 0.84 | BTK (0.80) | BTKLCKEGFRITKJAK3 | |
| SCHEMBL14643776 | 0.84 | BTK (0.76) | BTKLCKEGFRITKJAK3 | |
| SCHEMBL15517391 | 0.83 | BTK (0.72) | BTKLCKEGFRITKJAK3 | |
| SCHEMBL14644523 | 0.83 | BTK (0.72) | BTKLCKEGFRITKJAK3 | |
| SCHEMBL409224 | 0.83 | BTK (0.75) | BTKLCKEGFRITKJAK3 | |
| SCHEMBL28477160 | 0.83 | BTK (0.66) | BTKLCKEGFRITKJAK3 | |
| SCHEMBL410068 | 0.82 | BTK (0.82) | BTKLCKEGFRITKJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200289515-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE FOR THE TREATMENT OF SOLID TUMORS | PHARMACYCLICS, INC. | 2020-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200289515-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE FOR THE TREATMENT OF SOLID TUMORS | BTK, ABL1, LYN | BTK 1/4885LCK 8/4885EGFR 497/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.